Prediction of resistance to erythromycin in the genus Rickettsia by mutations in L22 ribosomal protein
نویسندگان
چکیده
منابع مشابه
Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli
L4 and L22, proteins of the large ribosomal subunit, contain globular surface domains and elongated 'tentacles' that reach into the core of the large subunit to form part of the lining of the peptide exit tunnel. Mutations in the tentacles of L4 and L22 confer macrolide resistance in a variety of pathogenic and non-pathogenic bacteria. In Escherichia coli, a Lys-to-Glu mutation in L4 and a thre...
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We characterized the effects of classical erythromycin resistance mutations in ribosomal proteins L4 and L22 of the large ribosomal subunit on the kinetics of erythromycin binding. Our data are consistent with a mechanism in which the macrolide erythromycin enters and exits the ribosome through the nascent peptide exit tunnel, and suggest that these mutations both impair passive transport throu...
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Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus.
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2005
ISSN: 1460-2091,0305-7453
DOI: 10.1093/jac/dki242